life sciences innovations
bioresorbable polymers platform innovations
Ashland's bioresorbable polymers innovation platform has primary applications in life science.
Designed for use in the pharmaceutical and medical industries, the platform portfolio contains
- many GMP grades,
- viatel™ ultrapure high-purity bioresorbable polymers for long-acting injectables and implants
- customized lactide/glycolide/caprolactone based polyester chemistries
In pharmaceutical applications, formulators typically use these polymers to formulate long-acting injectables (LAI’s) or controlled release systems that are realized in microsphere, nanoparticle, solid implant, in-situ depots, sustained release coatings, long-acting orals (LAO’s) or transdermal microneedle delivery formats.
In medical device applications, these polymers are used to fabricate degradable devices such as orthopedic screws and plates, vascular grafts, meshes and sutures. In regenerative medicine, these polymers are widely used to create dermal fillers to reduce appearance of lines and wrinkles, and in tissue engineering scaffolds to support cellular and tissue growth.
Bioresorbable polymers are easily broken down or excreted by the body and are designed to support the needs of drug formulation and medical device strategies.
products derived from the bioresorbable polymers platform:
other innovations
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next-gen controlled release polymers
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long acting injectables
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Ashland pharmaceuticals - coatings
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Ashland pharmaceuticals - continuous manufacturing |
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Ashland pharmaceuticals - controlled release
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Ashland pharmaceuticals - injectables |
related published innovation papers
| title/description | authors | related technologies |
|---|---|---|
| The aim of this study was to develop a hydrophilic oral controlled release system (CRS) using the amorphous form of gliclazide, a BCS class II compound, listed on the WHO list of essential medicines. For this purpose, spray-dried dispersions (SDDs) of gliclazide were produced using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) or copovidone as carrier under fully automated conditions | Lu, Zheng, Yonglai Yang, Rae-Ann Covington, Yunxia Vivian Bi, Thomas Dürig, and Reza Fassihi | polysaccharides, acetylenics |
| Cocrystals, Coamorphous Phases and Coordination Complexes of γ-and ε-Lactams | Hall, Amy V., Luke I. Chambers, Osama M. Musa, and Jonathan W. Steed | acetylenics |
| Development of carvedilol-cyclodextrin inclusion complexes using fluid-bed granulation: a novel solid-state complexation alternative with technological advantages | Ellen C P Alonso, Karina Riccomini, Luis Antônio D Silva, Daniela Galter, Eliana M Lima, Thomas Durig, Stephania F Taveira, Felipe Terra Martins, Marcílio S S Cunha-Filho, Ricardo N Marreto | polysaccharide |
| The preparation of graft copolymers of cellulose and cellulose derivatives using ATRP under homogeneous reaction conditions | Joubert, F., Musa, O. M., Hodgson, D. R. W., & Cameron | polysaccharide |
| Cyclodextrin-Efavirenz Complexes Investigated by Solid State and Solubility Studies | Braga, Susana S., Karyna Lysenko, Firas El-Saleh, and Filipe A.A. Paz | polysaccharide |
| Radiochromic Film as a Tool for Development of Sun Protection | Duev, A., Dueva-Koganov, O. V., Shih, S., Crohn, R., Aydin, R., & Menchon, M. | acetylenics |
| Is It Possible to Publish a Calibration Function for Radiochromic Film? | Chan, Maria F., Lewis D., Xiang Yu | acetylenics |
| Inclusion Compound of Efavirenz and γ-Cyclodextrin: Solid State Studies and Effect on Solubility | Braga, S. S., El-Saleh, F., Lysenko, K., & Paz, F. A. A. | acetylenics |
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This work aimed at obtaining an optimized itraconazole (ITZ) solid oral formulation in terms of palatability and dissolution rate by combining different polymers using hot melt extrusion (HME), according to a simplex centroid mixture design. For this, the polymers Plasdone® (poly(1-vinylpyrrolidone-co-vinyl acetate) [PVP/VA]), Klucel® ELF (2-hydroxypropyl ether cellulose [HPC]), and Soluplus® (SOL, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol) were processed using a laboratory HME equipment operating without recirculation at constant temperature. |
Malaquias, L. F. B., Schulte, H. L., Chaker, J. A., Karan, K., Durig, T., Marreto, R. N., Gratieri, T., Gelfuso, G. M., & Cunha-Filho | polysaccharides, acetylenics |
| Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms | Mogen AB, Chen F, Ahn SJ, Burne RA, Wang D, et al. | functional molecules |
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To enhance oral bioavailability and antioxidant potential of resveratrol by fabricating the resveratrol encapsulated oral eudragit® E100 based polymeric nano-delivery system. |
Hasija, R., S. Chaurasia, and Swati Gupta | acetylenics |
| Resveratrol-Loaded Poly(d,l-Lactide-Co-Glycolide) Microspheres Integrated in a Hyaluronic Acid Injectable Hydrogel for Cartilage Regeneration | Wang, X., Li, X., Duffy, P., McMahon, S., Wang, X., Lyu, J., Xu, Q., A, S., Chen, N.N., Bi, V., Dürig, T. and Wang, W. | polyesters |
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The formulations without Eudragit E PO (F6) and with Eudragit E PO (F7) filaments exhibited the desired hardness with a “k” value of 48.30 ± 3.52 and 45.47 ± 3.51 g/mm3 (n = 10), respectively, and were successfully printed. |
Wang, H., Dumpa, N., Bandari, S. Durig, H | acetylenics |
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Binary, ternary and quaternary dispersions containing GF, enteric polymer (Eudragit L100-55 or AQOAT-LF) and/or vinyl pyrrolidone-based polymer (Plasdone K-12 povidone or S-630 copovidone) were processed by HME. |
Ryan C Bennett, Justin M Keen, Yunxia (Vivian) Bi, Stuart Porter, Thomas Dürig, James W McGinity | acetylenics |
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