topical dosage
Pharmaceutical topical dosages contain a combination of active pharmaceutical ingredients (APIs) and inactive ingredients called excipients that help with the formulation, stability, and delivery of the APIs to the target site.
Ashland topical dosage excipients include:
- pharmasolve™ n-methyl-2-pyrrolidone (NMP) that is used as both a drug solubilizer and penetration enhancer in human and animal topical dosage.
- natrosol™ 250 h pharm hydroxyethylcellulose that is a thickener/viscosity modifier that helps provide the semi-solid consistency in gels, creams, and ointments.
- povidone-iodine, a water-soluble complex of iodine and the polymer polyvinylpyrrolidone (PVP), that is a widely used antiseptic and disinfectant agent with broad-spectrum antimicrobial activity. It is commonly used in medical settings as a general topical antiseptic used preoperatively, for treating wounds, hand hygiene, gargles, eyedrops, and mucous membrane disinfection.
- klucel™ hpc that is a non-ionic water-soluble cellulose ether used as a thickening agent in topical applications.
- allantoin™ usp that is a white colorless crystalline powder and a well-known skin and oral mucosa and wound care protectant. Allantoin usp meets current US Pharmacopeia (USP) and European Pharmacopeia (EP) monographs.
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pharmasolve™ n-methyl-2-pyrrolidone (NMP)
Pharmasolve™ n-methyl-2-pyrrolidone (NMP) is a versatile solubilizer for one-component systems. It is a water-miscible polar aprotic solvent with high interfacial activity. Pharmasolve™ NMP is manufactured in a facility with ISO 9001:2015 and EXCiPACT GMP certifications. It is used as a drug solubilizer and penetration enhancer in human and animal parenteral dosage forms.
plasdone™ povidone
Ashland offers a comprehensive range of Plasdone™ povidones (PVP). Plasdone™ povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms. Plasdone™ povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation or direct compression. Plasdone&trade...
klucel™ hydroxypropylcellulose
Klucel™ hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties. It combines organic solvent solubility, thermoplasticity and surface activity with the aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose polymers available from Ashland. Klucel™ HPC films are flexible without plasticizers and non-tacky at high humidity.
natrosol™ pharm HEC
Natrosol™ pharm HEC grades are non-ionic, water-soluble polymer widely used in pharmaceutical formulations. This product is easily dispersed in cold or hot water to give solutions of varying viscosities and desired properties, though it is insoluble in organic solvents. It is used in solutions and gels to control rheology, in emulsions for high-salt tolerance and surfactant compatibility, and in modified-release matrix tablets where high-vi...
natrosol™ 250 g pharm hydroxyethylcellulose
Hydroxyethylcellulose (HEC) is a non-ionic, water-soluble polymer widely used in pharmaceutical formulations.
natrosol™ 250 l pharm hydroxyethylcellulose
Hydroxyethylcellulose (HEC) is a non-ionic, water-soluble polymer widely used in pharmaceutical formulations.
natrosol™ 250 hhx pharm hydroxyethylcellulose
Hydroxyethylcellulose (HEC) is a non-ionic, water-soluble polymer widely used in pharmaceutical formulations.
natrosol™ 250 hx pharm hydroxyethylcellulose
Hydroxyethylcellulose (HEC) is a non-ionic, water-soluble polymer widely used in pharmaceutical formulations.
natrosol™ 250 m pharm hydroxyethylcellulose
Hydroxyethylcellulose (HEC) is a non-ionic, water-soluble polymer widely used in pharmaceutical formulations.
natrosol™ 250 h pharm hydroxyethylcellulose
Hydroxyethylcellulose (HEC) is a non-ionic, water-soluble polymer widely used in pharmaceutical formulations.
pharmasolve™ n-methyl-2-pyrrolidone
Pharmasolve™ n-methyl-2-pyrrolidone GMP grade can be used to improve the solubility of poorly soluble drugs and has a history of use with many medicines including human as well as veterinary products. Furthermore, in contrast to other drug-solubilizing agents, it has a favorable toxicity profile.