polyplasdone™ xl-10 crospovidone
chemistry: vp and derivatives
chemical name: polyvinylpolypyrollidone
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Polyplasdone™ crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of N-vinyl-2-pyrrolidone. Polyplasdone™ crospovidone particles are granular and porous compared with other superdisintegrants. The high surface area combined with unique chemistry results in high interfacial activity that enhances the dissolution of poorly water-soluble active pharmaceutical ingredients (APIs) in a way that is not possible with other disintegrant technologies.
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features and benefits - provides rapid disintegration in wet and dry granulation and direct compression tablet processes
- combines multiple mechanisms to achieve disintegration at low use levels (2-5 wt%)
- swells without forming gels that can slow tablet disintegration or dissolution
- increases tablet breaking force and reduces friability
- enhances the dissolution of poorly soluble drugs
- available in Type A and Type B crospovidone grades
- polyplasdone™ ultra and ultra-10 grades provide the same great performance with very low peroxide levels
applications - disintegration
- drug solubilization
- suspending agent
region currently available
For country-specific details, please contact your local sales representative.
Asia Pacific / China / Europe Middle East & Africa / Latin America / North America
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