plasdone™ k-90 povidone
chemistry: vp and derivatives
chemical name: polyvinylpyrrolidone
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Plasdone™ povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms. Plasdone™ povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation, or direct compression. Plasdone™ K polymers are used in solid dispersion formulations to enhance the solubility of active pharmaceutical ingredients and increase bioavailability. Plasdone™ K grades are also used to inhibit recrystallization in liquid soft gels.
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features and benefits - highly adhesive polymer- excellent tablet binding capacity at low concentrations producing hard, non-friable tablets
- excellent solubility in water and non-polar solvents- can be added as an aqueous or non-aqueous solution to wet granulation tablet processes
- dissolves quickly- does not delay disintegration or dissolution
- low solution viscosity- workable solution viscosity at high polymer levels makes it easy to use in granulation and other manufacturing equipment
- non-ionic- solution- viscosity is not affected by changes in pH or the presence of electrolytes, will not form complexes or interact with ionic drug actives
- interfacially active- acts as a drug solubilizer, inhibits crystallization of drug actives and inactive ingredients, stabilizes suspensions, dispersions and emulsions
applications - tablet binding
- modified release
- viscosifier
- tissue engineering scaffolds
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