klucel™ xtend hydroxypropylcellulose (HPC) controlled release matrix former
Klucel™ xtend hydroxypropyl cellulose (HPC) controlled release matrix former is designed to deliver unsurpassed process versatility and release profile efficiency. It is the latest addition to our Klucel™ product line and further expands our controlled-release portfolio.
Until now, there were limited options for managing the release profile of formulations, especially high dose, controlled release formulations. Ashland’s step change klucel™ xtend HPC has been shown to match the release profile of hypromellose controlled-release formulations at half the polymer concentration. The highly reduced polymer concentration achievable with klucel™ xtend HPC offers the possibility of smaller pills or higher dosage, if necessary. This new excipient offers unrivaled versatility across a broad range of APIs in every manufacturing process: dry granulation, wet-granulation, direct compression, and holt-melt extrusion.
The need for hot-melt extrusion (HME) polymers is expected to grow as the pharma industry moves to implement more continuous and sustainable processes. klucel™ xtend HPC is the only cellulosic excipient that provides a compendial extended-release polymer option for plasticizer-free HME.
This oral matrix former is the new gold standard for extended-release tablets.
klucel™ xtend HPC extending your options for
- highly soluble APIs
- high drug load formulations
- melt granulation or HME processing
- increased patient compliance
- complex formulations
features
- high gel strength
- low melt processing temperature
- process versatility
benefits
- consistent release profiles at lower concentrations than hydroxypropyl methylcellulose (HPMC)
- reduced burst effect in highly soluble APIs
- enables the development of smaller tablets and improves consumer usability
- excellent performance in direct compression, wet granulation, dry granulation, and hot melt extrusion
- plasticizer-free HME processability
- meets all compendia for HPC
And submit the literature download form on the right to download more information and data about klucel™ xtend HPC.
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view our klucel™ xtend webinar
Learn how Ashland’s step change hydroxypropyl cellulose, klucel™ xtend hpc, has been shown to match the release profile of widely used hypromellose controlled-release formulations at half the polymer concentration.
visit with us about Klucel xtend™ hpc at:
- API China 2024, May 15, Shanghai, China
- 15th Global Drug Delivery and Formulation Summit 2024, May 21, Berlin, Germany, booth #5
- FCE/Pharma 2024, June 4, Sao Paulo, Brazil, booth #C001
- CPHI Thailand 2024, July 10, Bangkok, Thailand
- CPHI Milan 2024, October 8, Fiera Milano, Italy, booth #6D20
- AAPS PHARMSCI 360 2024, October 20, Salt Lake City, UT booth #1903
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